Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors.

Amit TiroshSanjit MukherjeeJustin LackSudheer Kumar GaraSophie WangMartha M QuezadoXavier M KeutgenXiaolin WuMaggie CamSuresh KumarDhaval PatelNaris NilubolMonica Varun TyagiElectron Kebebew

Published in: Cancer (2019)

MEN1 NFPanNETs have a higher rate of geno me-wide hypermethylation than other NFPanNET subtypes. The similarity between the pathways enriched in a methylation analysis of known genes involved in NFPanNET tumorigenesis suggests a key role for aberrant methylation in the pathogenesis of NFPanNETs.

Keyphrases

genome wide
dna methylation
neuroendocrine tumors
copy number
gene expression
late onset
middle aged
amyotrophic lateral sclerosis