Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.
Thinzar M LwinRobert M HoffmanMichael BouvetPublished in: Journal of surgical oncology (2018)
Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe evaluation and highlights the advantages of patient-derived orthotopic xenografts (PDOX) mouse models and genetic reporters to develop fluorescence-guided surgery.
Keyphrases
- mouse model
- minimally invasive
- coronary artery bypass
- single molecule
- surgical site infection
- energy transfer
- robot assisted
- genome wide
- small molecule
- living cells
- prostate cancer
- cell therapy
- percutaneous coronary intervention
- stem cells
- copy number
- coronary artery disease
- gene expression
- rectal cancer
- acute coronary syndrome
- atrial fibrillation
- dna methylation