Synthesis of Multifunctional α,α-Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates.

The first allylic alkylation of difluoroenoxysilanes with MBH carbonates catalyzed by triethylenediamine (DABCO) is developed, which allows rapid access to multifunctional α-gem-difluoroketones with up to 97% yields. Moreover, the gram-scale synthesis and the diversifying transformation of products to valuable gem-difluorinated molecules highlight the practicality of this methodology.