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Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma.

Esther E E DreesJulia DriessenGerben J C ZwezerijnenSandra A W M VerkuijlenJakoba Johanna EertinkMonique A J van EijndhovenNils J GroenewegenAndrea Vallés-MartíDaphne de JongRonald BoellaardHenrica C W de VetDirk Michiel PegtelJosée J M Zijlstra-Baalbergen
Published in: EJHaem (2022)
Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18 F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.
Keyphrases
  • hodgkin lymphoma
  • pet ct
  • positron emission tomography
  • pet imaging
  • computed tomography
  • high resolution
  • high intensity