The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer's disease transgenic experimental models.

Javad AminiNaser SanchooliMohammad-Hossein MilajerdiMaryam BaeeriMohammad HaddadiNima Sanadgol

Published in: The International journal of neuroscience (2023)

Overall, we suggest that the neuropathological effects of tau aggregates may be accelerated brain aging, where redox signaling and autophagy efficacy play an important role.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
cognitive decline
resting state
white matter
cerebrospinal fluid
functional connectivity
cerebral ischemia