Favourable Tolerability and Drug Survival of Tioguanine Versus Methotrexate After Failure of Conventional Thiopurines in Crohn's Disease.
Edo H J SavelkoulM H J MaasArno R BourgonjeFemke CrouwelVince B C BiemansN den BroederM G V M RusselT E H RömkensN K de BoerG DijkstraF HoentjenPublished in: Journal of Crohn's & colitis (2022)
We observed a higher cumulative discontinuation incidence due to adverse events for methotrexate [44%] compared with tioguanine [17%] in Crohn's disease patients after failure of conventional thiopurines. The total adverse events incidence during methotrexate use was higher, whereas serious adverse events incidence was similar. These favourable results for tioguanine treatment may guide the selection of immunosuppressive therapy after failure of conventional thiopurines.