Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways.
Szabina Szófia SzilágyiAyelet R Amsalem-ZafranKeren E ShapiraMarcelo EhrlichYoav I HenisPublished in: BMC biology (2022)
Different type I receptors that signal to distinct Smad pathways (Smad2/3 vs. Smad1/5/8) compete for binding to common activin type II receptors. This provides a novel mechanism to balance signaling between Smad2/3 and Smad1/5/8.