Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

Ankit MahendraXingyu YangShaza AbnoufJay R T AdolacionDaechan ParkSanam SoomroJason RoszikCristian CoarfaGabrielle RomainKeith WanzeckS Louis BridgesAmita AggarwalPeng QiuSandeep K AgarwalChandra MohanNavin Varadarajan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

To the best of our knowledge, this is the first study to document the whole transcriptome profile of autoreactive B cells in any autoimmune disease. These data identify several genes and pathways that may be targeted by repurposing several US Food and Drug Administration-approved drugs, and could serve as the foundation for the comparative assessment of B cell profiles in other autoimmune diseases.

Keyphrases

drug administration
rheumatoid arthritis
single cell
genome wide
endothelial cells
healthcare
rna seq
disease activity
multiple sclerosis
gene expression
electronic health record
big data
drug induced
cancer therapy
machine learning
deep learning
dna methylation
genome wide identification