Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma.

Liye TaoYali WangZefeng ShenJingwei CaiJunhao ZhengShunjie XiaZhongjie LinZhe WanHaiou QiRenan JinLing WangJunjie XuJiang Chen

Published in: Hepatology international (2023)

In summary, our study revealed a novel mechanism of miR-122-5p and function of the miR-122-5p/IGFBP4 axis in the metastasis of ICC. We also highlighted the clinical value of miR-122-5p and IGFBP4 in inhibiting ICC invasion and metastasis.

Keyphrases

signaling pathway
single cell