Ultrasmall Ruthenium Nanoparticles with Boosted Antioxidant Activity Upregulate Regulatory T Cells for Highly Efficient Liver Injury Therapy.
Fan XiaXi HuBo ZhangXun WangYunan GuanPeihua LinZhiyuan MaJianpeng ShengDaishun LingFangyuan LiPublished in: Small (Weinheim an der Bergstrasse, Germany) (2022)
Nanozymes exhibiting antioxidant activity are beneficial for the treatment of oxidative stress-associated diseases. Ruthenium nanoparticles (RuNPs) with multiple enzyme-like activities have attracted growing attention, but the relatively low antioxidant enzyme-like activities hinder their practical biomedical applications. Here, a size regulation strategy is presented to significantly boost the antioxidant enzyme-like activities of RuNPs. It is found that as the size of RuNPs decreases to ≈2.0 nm (sRuNP), the surface-oxidized Ru atoms become dominant, thus possessing an unprecedentedly boosted antioxidant activity as compared to medium-sized (≈3.9 nm) or large-sized counterparts (≈5.9 nm) that are mainly composed of surface metallic Ru atoms. Notably, based on their antioxidant enzyme-like activities and ultrasmall size, sRuNP can not only sustainably ameliorate oxidative stress but also upregulate regulatory T cells in late-stage acetaminophen (APAP)-induced liver injury (ALI). Consequently, sRuNPs perform highly efficient therapeutic efficiency on ALI mice even when treated at 6 h after APAP intoxication. This strategy is insightful for tuning the catalytic performances of nanozymes for their extensive biomedical applications.
Keyphrases
- regulatory t cells
- highly efficient
- oxidative stress
- liver injury
- drug induced
- dendritic cells
- photodynamic therapy
- dna damage
- anti inflammatory
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- skeletal muscle
- iron oxide
- metabolic syndrome
- combination therapy
- newly diagnosed
- smoking cessation
- crystal structure
- wild type