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Big Bang and context-driven collapse.

Mark Robertson-TessiAlexander A R A Anderson
Published in: Nature genetics (2015)
Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.
Keyphrases
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