Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma.
Dipika R MohanAntonio Marcondes LerarioTobias ElseBhramar MukherjeeMadson Q AlmeidaMichelle VincoJuilee RegeBeatriz M P MarianiMaria Claudia N ZerbiniBerenice B MendoncaAna Claudia LatronicoSuely Kazue Nagahashi MarieWilliam E RaineyThomas J GiordanoMaria Candida B V FragosoGary D HammerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
G0S2 hypermethylation is a hallmark of rapidly recurrent or fatal ACC, amenable to targeted assessment using routine molecular diagnostics. Assessing G0S2 methylation is straightforward, feasible for clinical decision-making, and will enable the direction of efficacious adjuvant therapies for patients with aggressive ACC.