Covalent Organic Framework-Based Nanomotor for Multimodal Cancer Photo-Theranostics.

Developing efficient integrated diagnosis and treatment agents based on the fuel-free self-movement nanomotors remains challenging in antitumor therapy. In this study, we report a covalent organic framework (COF)-based biomimetic nanomotor composed of PPy core, porphyrin-COF shell and HCT116 cancer cell membrane coating. Under NIR light irradiation, the obtained mPPy@COF-Por can overcome Brownian motion and achieves directional motion through self-thermophoretic force generated from the PPy core. The HCT116 cancer cell membrane coating enables the nanomotor to selectively recognize the source cell lines and reduces the bio-adhesion of mPPy@COF-Por in biological medium, endowing with this NIR light-powered nanomotor a good mobility. More importantly, such multifunctional integration allows the COF-based nanomotor to be a powerful nanoagent for cancer treatment, and the high IRI/PAI/FLI trimodal imaging guided combined PTT/PDT therapeutic effect on HCT116 tumor cell is successfully achieved. Our results offer considerable promise for the development of COF-nanomotors with integrated imaging/therapy modalities in biomedical applications. This article is protected by copyright. All rights reserved.