Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the Seychelles Child Development Study.
Emeir Mary McSorleyAlison J YeatesMaria S MulhernEdwin van WijngaardenKatherine GrzesikSally W ThurstonToni SpenceWilliam CrowePhilip W DavidsonGrazyna ZarebaGary J MyersGene E WatsonConrad F ShamlayeJ J StrainPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
Maternal MeHg was associated with markers of immune function at 28 weeks' gestation. A significant interaction between MeHg and the n-6:n-3 ratio on the Th1:Th2 ratio suggests that the n-3 PUFA may mitigate any immunosuppressive associations of MeHg. The n-3 and n-6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance.