HLA-lacking clones in aplastic anaemia: Adaptive or maladaptive?

Carmelo GurnariAlberto Cardoso Martins LimaSimona Pagliuca

Published in: British journal of haematology (2024)

HLA loss represents the result of immune forces shaping bone marrow clonal dynamics in immune aplastic anaemia. Human leukocyte antigen (HLA)-deficient clones may rescue haematopoiesis by evading immune attacks, potentially guiding treatment strategies. Commentary on: Zaimoku et al. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19712.

Keyphrases

bone marrow
allogeneic hematopoietic stem cell transplantation
iron deficiency
stem cells
endothelial cells
mesenchymal stem cells
early onset
squamous cell carcinoma
acute lymphoblastic leukemia
radiation therapy
health information
induced pluripotent stem cells
locally advanced