Biadhesive Peptides for Assembling Stainless Steel and Compound Loaded Micro-Containers.
Lina ApitiusSven BuschmannChristian BergsDavid SchönauerFelix JakobAndrij PichUlrich SchwanebergPublished in: Macromolecular bioscience (2019)
Biadhesive peptides (peptesives) are an attractive tool for assembling two chemically different materials-for example, stainless steel and polycaprolactone (PCL). Stainless steel is used in medical stents and PCL is used as a biodegradable polymer for fabrication of tissue growth scaffolds and drug delivering micro-containers. Biadhesive peptides are composed of two domains (e.g., dermaseptin S1 and LCI) with different material-binding properties that are separated through a stiff peptide-spacer. The peptesive dermaseptin S1-domain Z-LCI immobilizes antibiotic-loaded PCL micro-containers on stainless steel surfaces. Immobilization is visualized by microscopy and field emission scanning electron microscopy analysis and released antibiotic from the micro-containers is confirmed through growth inhibition of Escherichia coli cells.
Keyphrases
- electron microscopy
- drug delivery
- escherichia coli
- tissue engineering
- high resolution
- induced apoptosis
- healthcare
- cancer therapy
- amino acid
- biofilm formation
- single molecule
- cell cycle arrest
- wound healing
- high throughput
- pseudomonas aeruginosa
- binding protein
- oxidative stress
- mass spectrometry
- klebsiella pneumoniae
- candida albicans
- multidrug resistant
- data analysis