Deficiency of kin17 Facilitates Apoptosis of Cervical Cancer Cells by Modulating Caspase 3, PARP, and Bcl-2 Family Proteins.

Bingsen Su Meifeng Zhong Yuzhao Zhang Kunhe Wu Qiyuan Huang Chuiyu Zhu Tao Zeng

Published in: Journal of oncology (2022)

Our findings demonstrated that kin17 knockdown facilitates apoptosis of cervical cancer cells by targeting caspase 3, PARP, and Bcl-2 family proteins. Besides, kin17 could regulate cancer cell apoptosis through the mitochondrial pathway and could be used as a novel therapeutic target for the regulation of cell apoptosis in cervical cancer.

Keyphrases

cell death
oxidative stress
cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
dna damage
dna repair
cell proliferation
papillary thyroid
signaling pathway
squamous cell
young adults