Early stimulated immune responses predict clinical disease severity in hospitalized COVID-19 patients.
Rebecca Svanberg TeglgaardCameron MacPhersonAdrian G ZuccoRudi AgiusTereza FaitovaMichael Asger AndersenCaspar da Cunha-BangLars Klingen GjaerdeMaria Elizabeth Engel MøllerPatrick Terrence BrooksBirgitte LindegaardAdin SejdicAnne Ortved GangDitte Stampe HersbyChristian BrieghelSusanne Dam NielsenDaria PodlekarevaAnnemette HaldJakob Thaning BayHanne Vibeke Hansen MarquartJens Dilling LundgrenAnne-Mette LebechMarie HellebergCarsten Utoft NiemannSisse Rye OstrowskiPublished in: Communications medicine (2022)
We identify early impairments in innate immune responses that are associated with subsequent COVID-19 disease severity. Our findings provide basis for early identification of patients at risk of severe disease which may have significant implications for the early management of patients hospitalized with COVID-19.