FOXD1 mutations are related to repeated implantation failure, intra-uterine growth restriction and preeclampsia.

Paula Quintero-RonderosKaren Marcela JiménezClara Esteban-PérezDiego A OjedaSandra BelloDora Janeth FonsecaMaría Alejandra CoronelHarold Moreno-OrtizDiana Carolina Sierra-DíazElkin LucenaSandrine BarbauxDaniel VaimanPaul Laissue

Published in: Molecular medicine (Cambridge, Mass.) (2019)

Our results argue in favour of FOXD1 mutations' central role in RPL, RIF, IUGR and PE pathogenesis via C3 and PlGF regulation and they describe, for the first time, a functional link between FOXD1 and implantation/placental diseases. FOXD1 could therefore be used in clinical environments as a molecular biomarker for these diseases in the near future.

Keyphrases

early onset
pulmonary tuberculosis
current status
pregnant women
mycobacterium tuberculosis
drug induced