Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infection in 17 middle- and high-income countries in Europe and Thailand: A cohort study.
null nullAli JuddElizabeth ChappellAnna TurkovaSophie Le CoeurAntoni Noguera-JulianTessa GoetghebuerKatja DoerholtLuisa GalliDasja PajkrtLaura MarquesIntira J CollinsDiana M GibbMaria Isabel González TomeMarisa Navarro GomezJosiane WarszawskiChristoph KönigsVana SpoulouFilipa PrataElena ChiappiniLars NavérCarlo GiaquintoClaire ThorneMagdalena MarczynskaLiubov OkhonskaiaKlara Posfay-BarbePradthana OunchanumPornchai TechakunakornGalina KiselevaRuslan MalyutaAlla VolokhaLuminita EneRuth L GoodallPublished in: PLoS medicine (2018)
In our study, 3,526 children and adolescents with perinatal HIV infection initiated antiretroviral therapy (ART) in countries in Europe and Thailand. We observed that over 40% of deaths occurred ≤6 months after cART initiation. Greater early mortality risk in infants, as compared to older children, and in Russia, Ukraine, or Thailand as compared to W&CE, raises concern. Current severe immune suppression, being underweight, and unsuppressed viral load were associated with a higher risk of death at >6 months after initiation of cART.