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ADP-ribosylation: from molecular mechanisms to human disease.

Nícolas Carlos HochLuis Mariano Polo
Published in: Genetics and molecular biology (2019)
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
Keyphrases
  • dna damage
  • endothelial cells
  • oxidative stress
  • induced pluripotent stem cells
  • healthcare
  • dna repair
  • papillary thyroid
  • squamous cell carcinoma
  • combination therapy
  • amino acid
  • lymph node metastasis