HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia.
Petra AlanovaLukas AlanBarbora OpletalovaRomana BohuslavovaPavel AbaffyKaterina MatejkovaKristyna HolzerovaDaniel BenakNina KaludercicRoberta MenaboFabio Di LisaBohuslav OstadalFrantisek KolarGabriela PavlinkovaPublished in: Acta physiologica (Oxford, England) (2024)
These findings provide new insights into the contribution of HIF-1α to cardiomyocyte survival during acute ischemia/reperfusion injury by activating the selective autophagy pathway.
Keyphrases
- ischemia reperfusion injury
- endothelial cells
- signaling pathway
- oxidative stress
- liver failure
- drug induced
- cell death
- heart failure
- high glucose
- respiratory failure
- endoplasmic reticulum stress
- left ventricular
- aortic dissection
- free survival
- hepatitis b virus
- nlrp inflammasome
- intensive care unit
- mechanical ventilation