Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice.

Ran WeiFang-Jiao ZongJiahao DongWei ZhaoFang-Fang ZhangWei WangShuang ZhaoZiqi WangFang ZhangHan-Ting Zhang

Published in: The international journal of neuropsychopharmacology (2024)

Inhibition or knockdown of PDE7A attenuates EtOH responsivenessand consumption exclusively in female mice, which is associated with alterations in the cAMP-PKA/Epac2 signaling pathways, thereby highlighting its potential as a novel therapeutic target for alcohol use disorder.

Keyphrases

alcohol use disorder
high fat diet induced
signaling pathway
adipose tissue
insulin resistance
binding protein
induced apoptosis