Neonatal encephalopathy due to suspected hypoxic ischemic encephalopathy: pathophysiology, current, and emerging treatments.
Carina Corte-Real BabboJuanita MelletJeanne van RensburgShakti PillayAlan Richard HornFirdose Lambey NakwaSithembiso Christopher VelaphiGugulabatembunamahlubi Tenjiwe Jabulile KaliMelantha CoetzeeMogomane Yvonne Khomotso MasemolaDaynia Elizabeth BallotMichael Sean PepperPublished in: World journal of pediatrics : WJP (2024)
This review describes the rationale and current evidence for alternative treatments in the context of the pathophysiology of HIE. Neuroprotective agents are currently only being investigated in high- and middle-income settings. Results from these trials will need to be interpreted and validated in LMIC settings. The focus of future research should therefore be on the development of inexpensive, accessible monotherapies and should include LMICs, where the highest burden of NESHIE exists.