Latent Class Analysis Identifies Distinct Phenotypes of Systemic Lupus Erythematosus Predictive of Flares after mRNA COVID-19 Vaccination: Results from the Coronavirus National Vaccine Registry for ImmuNe Diseases SINGapore (CONVIN-SING).
Tao Ming SimManjari LahiriMargaret MaPeter Pak-Moon CheungAnselm MakWeng Seng Warren FongStanley AngkodjojoChuanhui XuKok Ooi KongThaschawee ArkachaisriKee Fong PhangTeck Choon TanQai Ven YapYiong-Huak ChanMelonie SriranganathanTyng Yu ChuahNur Emillia RoslanYih Jia PohAnnie LawAmelia SantosaSen Hee TayPublished in: Vaccines (2023)
We identified two distinct phenotypic clusters of SLE with different patterns of flares following mRNA COVID-19 vaccination. Caution has to be exercised in monitoring for post-vaccination flares in patients with risk factors for flares such as non-Chinese ethnicity, young age, male gender and suboptimal disease control at the time of vaccination.