Dl-3-n-butylphthalide promotes synaptic plasticity by activating the Akt/ERK signaling pathway and reduces the blood-brain barrier leakage by inhibiting the HIF-1α/MMP signaling pathway in vascular dementia model mice.
Ping CheJuan ZhangMingqian YuPing TangYanhui WangAolei LinJing XuNan ZhangPublished in: CNS neuroscience & therapeutics (2023)
In conclusion, our results demonstrated the therapeutic effects of NBP in improving cognitive function via a wide range of targets in mice subjected to BCAS.