Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice.

Viktoria ZoufalSeverin MairingerMarkus KrohnThomas WanekThomas FilipMichael SaubererJohann StanekAlexander TraxlJohn D SchuetzClaudia KuntnerJens PahnkeOliver Langer

Published in: Molecular imaging and biology (2019)

Our data suggest that 6-bromo-7-[11C]methylpurine may be useful to assess the activity of MRPs in the kidneys as well as in other organs (brain, lungs), although further work is needed to identify the MRP subtypes involved in the disposition of 6-bromo-7-[11C]methylpurine-derived radioactivity.

Keyphrases

high resolution
white matter
electronic health record
resting state
big data
quantum dots
type diabetes
multiple sclerosis
metabolic syndrome
machine learning
fluorescence imaging
skeletal muscle
data analysis