Paper spray mass spectrometry - A potential complementary technique for the detection of polar compounds in sports drug testing.
Christian GörgensKatherine WalkerCornelia BoeserNeloni WijeratneClaudia MartinsSven GuddatMario ThevisPublished in: Drug testing and analysis (2020)
In this proof-of-concept study, paper spray mass spectrometry was investigated as a high-throughput and fully automated technique for the initial testing of particularly polar compounds that are prohibited in sports. The technique allows the ionization of analytes from complex sample matrices such as blood and urine when spotted onto a paper strip. By minimizing sample preparation and omitting chromatographic separation, paper spray mass spectrometry benefits from considerable cost- and time-savings compared with conventional high performance liquid chromatography/tandem mass spectrometry, especially in cases where conventional reversed-phase liquid chromatography offers limited applicability. All but one of the investigated model compounds fulfilled the World Anti-Doping Agency's (WADA's) requirements regarding the applicable minimum required performance limits for initial testing procedures. In addition, the combination of paper spray mass spectrometry and ion mobility separation results in enhanced selectivity and sensitivity and is a particularly valuable analytical configuration.
Keyphrases
- ionic liquid
- liquid chromatography
- mass spectrometry
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- high resolution mass spectrometry
- solid phase extraction
- gas chromatography
- high throughput
- high performance liquid chromatography
- molecularly imprinted
- capillary electrophoresis
- high resolution
- machine learning
- emergency department
- deep learning
- atomic force microscopy
- climate change
- ms ms
- quantum dots
- human health
- high speed