Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy.
Huiqiang WuSooho YeoJiazhu LiJinjun WangWoo Kyoung LeeIl YoonPublished in: ACS omega (2023)
In this study, we condensed methyl pyropheophorbide-a ( 2 ) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin ( 3a ) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV-visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry.
Keyphrases
- photodynamic therapy
- high resolution
- mass spectrometry
- magnetic resonance
- cell cycle arrest
- fluorescence imaging
- induced apoptosis
- liquid chromatography
- oxidative stress
- cell death
- single molecule
- cancer therapy
- gas chromatography
- magnetic resonance imaging
- tandem mass spectrometry
- pi k akt
- endoplasmic reticulum stress
- high speed
- quantum dots
- ms ms
- solid state
- energy transfer
- simultaneous determination
- solid phase extraction
- aqueous solution