Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea.
Mohammad BadranClementine PuechAbdelnaby KhalyfaRene CorteseKylie CataldoZhuanhong QiaoDavid GozalPublished in: American journal of respiratory and critical care medicine (2023)
These findings indicate that the reversibility of end-organ morbidities induced by OSA are not only contingent on restoration of normal oxygenation patterns and can be further enhanced by targeting other OSA-mediated detrimental cellular processes, such as accelerated senescence.