MEOX2 homeobox gene promotes growth of malignant gliomas.

Anna SchönrockElisa HeinzelmannBianca StefflEngin DemirdizenAshwin NarayananDamir KrunicMarion BährJong-Whi ParkClaudia SchmidtKoray ÖzdumanM Necmettin Pamir Wolfgang WickFelix BestvaterDieter Weichenhan Christoph Plass Julian Taranda Moritz Mall Şevin Turcan

Published in: Neuro-oncology (2022)

We identified MEOX2 as an oncogenic transcription regulator in GBM. MEOX2 increases proliferation in cerebral organoid models of GBM and feeds into ERK signaling that represents a core signaling pathway in GBM.

Keyphrases

signaling pathway
transcription factor
pi k akt
induced apoptosis
epithelial mesenchymal transition
high grade
subarachnoid hemorrhage
genome wide identification
cell proliferation
gene expression
brain injury
blood brain barrier