CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.

Xuehan Chen Yanzhuo Liu Yang Wang Chenlong Wang Xuewei Chen Yu Xiong Lilong Liu Xi Yuan Honglin Tang Chong Shu Jing Zhang Austin M Guo Honglei Chen Jing Yang

Published in: Cancer research (2022)

The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strategy to improve the efficacy of immunotherapy by inhibiting CYP4F2. See related article by Van Ginderachter, p. 3882.

Keyphrases

single cell
signaling pathway
bone marrow
cell therapy
room temperature
stem cells
mesenchymal stem cells
drug induced