A Model-Informed Method for the Purpose of Precision Dosing of Isoniazid in Pulmonary Tuberculosis.
Stijn W van BeekRob Ter HeineJan-Willem C AlffenaarCecile Magis-EscurraRob E AarnoutseElin M Svenssonnull nullPublished in: Clinical pharmacokinetics (2021)
A model-based therapeutic drug monitoring strategy for personalized dosing of isoniazid using sampling at 2 and 4 h after dosing was successfully developed. Prospective evaluation of this strategy will show how it performs in a clinical therapeutic drug monitoring setting.