Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis.

Wenwei QianLiang-Yu HuangYihan XuWen LuWeiwei WenZhen GuoWeiming ZhuYi Li

Published in: Inflammatory bowel diseases (2022)

Exosomal miR-216a-5p released from hypoxia-prime ASCs showed higher therapeutic efficiency than NExos in experimental colitis by promoting the M2 macrophage phenotype, which indicated that hypoxia prime may represent a promising approach to optimizing the function of ASC-derived exosomes.

Keyphrases

mesenchymal stem cells
stem cells
endothelial cells
adipose tissue
ulcerative colitis
nlrp inflammasome