Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage.

Aletta van den BoschNina L FransenMatthew MasonAnnemieke Johanna RozemullerCharlotte E Teunissen Joost J F M SmoldersInge Huitinga

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

Our results demonstrated that active and mixed white matter MS lesions with foamy microglia show high acute axonal damage and correlate with elevated CSF NfL levels. Our data support the use of this biomarker to monitor inflammatory demyelinating lesion activity with axonal damage in MS.

Keyphrases

multiple sclerosis
white matter
oxidative stress
spinal cord injury
liver failure
mass spectrometry
respiratory failure
ms ms
drug induced
aortic dissection
optic nerve
neuropathic pain
inflammatory response
cerebrospinal fluid
extracorporeal membrane oxygenation
peripheral nerve