Gene therapy decreases seizures in a model of Incontinentia pigmenti.

Godwin K DogbeviaKathrin TöllnerJakob KörbelinSonja BröerDirk A RidderHanna GrasshoffClaudia BrandtJan WenzelBeate K StraubMartin TrepelWolfgang LöscherMarkus Schwaninger

Published in: Annals of neurology (2017)

The data show that the BBB is a target of antiepileptic treatment and, more specifically, provide evidence for the therapeutic benefit of a brain endothelial-targeted gene therapy in IP. Ann Neurol 2017;82:93-104.

Keyphrases

gene therapy
endothelial cells
electronic health record
resting state
big data
functional connectivity
machine learning
multiple sclerosis
neural network
drug delivery
smoking cessation