Prognostic value of preoperative mechanical hyperalgesia and neuropathic pain qualities for postoperative pain after total knee replacement.
Andrew D VigotskyOlivia CongCamila B PintoJoana BarrosoJennifer PerezKristian Kjaer PetersenLars Arendt-NielsenKevin D HardtDavid ManningA Vania ApkarianPaulo BrancoPublished in: European journal of pain (London, England) (2024)
This study's findings hold significant implications for chronic pain management in knee osteoarthritis patients, particularly those undergoing total knee replacement surgery (TKR). Mechanical hyperalgesia and neuropathic pain-like characteristics predict postoperative pain 1 year after TKR, emphasizing the importance of understanding pain phenotypes in OA for selecting appropriate pain management strategies. The normalization of hyperalgesia after surgery correlates with better long-term outcomes, further highlighting the therapeutic potential of addressing abnormal pain processing mechanisms pre- and post-TKR.
Keyphrases
- neuropathic pain
- pain management
- knee osteoarthritis
- postoperative pain
- spinal cord
- spinal cord injury
- chronic pain
- end stage renal disease
- total knee arthroplasty
- newly diagnosed
- ejection fraction
- chronic kidney disease
- minimally invasive
- prognostic factors
- patient reported outcomes
- percutaneous coronary intervention
- coronary artery disease
- patient reported
- surgical site infection
- atrial fibrillation