Protease-activated receptor 2 enhances innate and inflammatory mechanisms induced by lipopolysaccharide in macrophages from C57BL/6 mice.

Ayslan BarraAmanda Ferreira BrasilThaís Lemos FerreiraWeslley Fernandes-BragaDanielle Gomes MarconatoPriscila Faria-PintoJacqueline Isaura Alvarez-LeiteLuciano Dos Santos Aggum CapettiniAndré Klein

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)

This study provides evidence of a role for PAR2 in macrophage response triggered by LPS enhancing the phagocytic activity and NO, ROS, and cytokine production, resulting in the initial and adequate macrophage response required for their innate response mechanisms.

Keyphrases

immune response
inflammatory response
oxidative stress
toll like receptor
dna damage
cell death
metabolic syndrome
skeletal muscle
high fat diet induced