A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis.
Wei FanShuhao ZengXiaotang WangGuoqing WangDan LiaoRuonan LiSiyuan HeWanqian LiJiaxing HuangXingran LiJiangyi LiuNa LiShengping HouPublished in: Genome biology (2024)
Collectively, our study illustrates that H3K9la is important for VEGF-induced angiogenesis, and interruption of the H3K9la/HDAC2 feedback loop may represent a novel therapeutic method for treating pathological neovascularization.