MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.

Maorong JiangRan LiJingjun LyuXuan LiWei WangZhuoran WangHuaxin ShengWeiguo ZhangJörn KarhausenWei Yang

Published in: Journal of neuroinflammation (2020)

Our data demonstrate that activation of NLRP3 inflammasome could be a key event shaping the post-CA immuno- and neuro-pathology, and identify this pathway as a unique and promising therapeutic target to improve outcomes after CA/CPR.

Keyphrases

cardiac arrest
nlrp inflammasome
cardiopulmonary resuscitation
protein kinase
electronic health record
big data
machine learning
artificial intelligence
data analysis
deep learning