18F-FDG PET and DCE kinetic modeling and their correlations in primary NSCLC: first voxel-wise correlative analysis of human simultaneous [18F]FDG PET-MRI data.

Florent L BessonBrice FernandezSylvain FaureOlaf MercierAndrei SeferianXavier MignardSacha MussotCecile le PechouxCaroline CaramellaAngela BotticellaAntonin LevyFlorence ParentSophie BulifonDavid MontaniDelphine MitilianElie FadelDavid PlanchardBenjamin BesseMaria-Rosa Ghigna-BellinzoniClaude ComtatVincent LebonEmmanuel Durand

Published in: EJNMMI research (2020)

A dynamic "one-stop shop" procedure applied to NSCLC is technically feasible in clinical practice. PET and DCE kinetic parameters assessed simultaneously are not highly correlated in NSCLC, and these correlations showed a wide variability among tumors and patients. These results tend to suggest that PET and DCE kinetic parameters might provide complementary information. In the future, this might make PET-MRI a unique tool to characterize the individual tumor biological behavior in NSCLC.

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