18F-FDG PET and DCE kinetic modeling and their correlations in primary NSCLC: first voxel-wise correlative analysis of human simultaneous [18F]FDG PET-MRI data.
Florent L BessonBrice FernandezSylvain FaureOlaf MercierAndrei SeferianXavier MignardSacha MussotCecile le PechouxCaroline CaramellaAngela BotticellaAntonin LevyFlorence ParentSophie BulifonDavid MontaniDelphine MitilianElie FadelDavid PlanchardBenjamin BesseMaria-Rosa Ghigna-BellinzoniClaude ComtatVincent LebonEmmanuel DurandPublished in: EJNMMI research (2020)
A dynamic "one-stop shop" procedure applied to NSCLC is technically feasible in clinical practice. PET and DCE kinetic parameters assessed simultaneously are not highly correlated in NSCLC, and these correlations showed a wide variability among tumors and patients. These results tend to suggest that PET and DCE kinetic parameters might provide complementary information. In the future, this might make PET-MRI a unique tool to characterize the individual tumor biological behavior in NSCLC.
Keyphrases
- pet ct
- positron emission tomography
- pet imaging
- small cell lung cancer
- contrast enhanced
- computed tomography
- advanced non small cell lung cancer
- magnetic resonance imaging
- brain metastases
- end stage renal disease
- newly diagnosed
- endothelial cells
- magnetic resonance
- diffusion weighted imaging
- machine learning
- electronic health record
- healthcare
- minimally invasive
- current status
- health information
- prognostic factors
- tyrosine kinase
- induced pluripotent stem cells
- data analysis