Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity.

Theresa SchöttlFiona PachlPieter GiesbertzHannelore DanielBernhard Kuster Tobias Fromme Martin Klingenspor

Published in: Obesity (Silver Spring, Md.) (2020)

Protein components of the OXPHOS machinery are systematically downregulated in adipose tissues of DIO mice compared with lean mice. Loss of the mitochondrial OXPHOS capacity in adipocytes may aggravate the development of metabolic disease.

Keyphrases

high fat diet induced
insulin resistance
adipose tissue
metabolic syndrome
skeletal muscle
type diabetes
oxidative stress
gene expression
weight loss
cell death
single cell
amino acid
protein protein
bone mineral density
small molecule
label free
physical activity
reactive oxygen species