Interstitial laser anterior capsulotomy for obsessive-compulsive disorder: lesion size and tractography correlate with outcome.

David SatzerAnil MahavadiMaureen LacyJon E GrantPeter Warnke

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

Laser anterior capsulotomy resulted in immediate, marked improvement in OCD symptom severity. Larger lesions permit greater disconnection of prefrontal-subcortical pathways involved in OCD. The importance of greater disconnection is presumably related to variation in ALIC structure and the complex role of the PFC in OCD.

Keyphrases

obsessive compulsive disorder
deep brain stimulation
white matter
high speed
working memory
functional connectivity
transcranial magnetic stimulation
multiple sclerosis
drug induced