Monogenic and Polygenic Contributions to QTc Prolongation in the Population.
Victor NauffalValerie N MorrillSean Joseph JurgensSeung Hoan ChoiAmelia W HallLu-Chen WengJennifer L HalfordChristina A Austin-TseChristopher M HaggertyStephanie L HarrisEugene K WongAlvaro AlonsoDan E ArkingEmelia J BenjaminEric BoerwinkleYuan-I MinAdolfo CorreaBrandon K FornwaltSusan R Heckbertnull nullCharles KooperbergHenry J LinRuth J F LoosKenneth M RiceNamrata GuptaThomas W BlackwellBraxton D MitchellAlanna C MorrisonBruce M PsatyWendy S PostSusan RedlineMichael J BamshadStephen S RichJerome I RotterElsayed Z SolimanNona SotoodehniaKathryn L LunettaPatrick T EllinorSteven A Lubitznull nullPublished in: Circulation (2022)
QTc duration in the population is influenced by both rare variants in genes underlying cardiac repolarization and polygenic risk, with a sizeable contribution from polygenic risk. Comprehensive assessment of the genetic determinants of QTc prolongation includes incorporation of both polygenic and monogenic risk.