Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles.

Thomas Ravn LassenJesper JustMarie Vognstoft HjortbakNichlas Riise JespersenKatrine Tang StenzTingting GuYan YanJunyi SuJakob HansenRikke BækMalene Møller JørgensenJens Randel NyengaardSteen Buus KristiansenKim Ryun DrasbekJørgen KjemsHans Erik Bøtker

Published in: Basic research in cardiology (2021)

Cardioprotection by RIC can be mediated by circulating EVs that accumulate in injured myocardium. The underlying mechanism involves modulation of EV miRNA that may promote cell survival during reperfusion.

Keyphrases

cerebral ischemia
acute myocardial infarction
acute ischemic stroke
oxidative stress
left ventricular
atrial fibrillation