Prepubertal children with obesity have high free IGF-1 levels and accelerated growth despite reduced pappalysin levels.

Álvaro Martín-Rivada Gabriel Ángel Martos-Moreno Santiago Guerra-CanteraAna Campillo-CalatayudClaus Oxvig Jan Frystyk Julia A Chowen Vicente Barrios-Sabador Jesús Argente

Published in: The Journal of clinical endocrinology and metabolism (2024)

Increased circulating total and free IGF-I, insulin and IGF-II may all contribute to the increased rate of prepubertal growth and bone maturation observed in children with obesity, with STC2 possibly being involved.

Keyphrases

growth hormone
type diabetes
insulin resistance
metabolic syndrome
weight loss
young adults
pi k akt
binding protein
high fat diet induced
glycemic control
adipose tissue
cell proliferation
postmenopausal women