Etiology of Retinal and Cerebellar Pathology in Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex.
Peter S SpencerPublished in: Eye and brain (2020)
ALS/PDC-associated retinal and cerebellar dysplasia could arise from in utero exposure to methylazoxymethanol, the genotoxic metabolite of cycasin that results from maternal ingestion of this azoxyglucoside. These results support the environmental toxic etiology of retinal and brain pathology in ALS/PDC.
Keyphrases
- amyotrophic lateral sclerosis
- optical coherence tomography
- diabetic retinopathy
- optic nerve
- mild cognitive impairment
- white matter
- south africa
- physical activity
- drug induced
- parkinson disease
- birth weight
- resting state
- risk assessment
- multiple sclerosis
- climate change
- pregnant women
- pregnancy outcomes
- blood brain barrier
- human health