Mitigating cognitive deficits with teriflunomide: unraveling PI3K-modulated behavioral outcomes in mice.

Published in: Molecular biology reports (2024)

Our results delineate that the improvement in memory, locomotion, and motor coordination might be attributed to the oxidative and inflammatory stress inhibitory potential of teriflunomide. Moreover, PI3K inhibition-induced memory impairment might be attributed to reduced GSH levels and increased TNF-α levels.

Keyphrases

working memory
rheumatoid arthritis
high glucose
oxidative stress
high fat diet induced
type diabetes
human health
fluorescent probe
risk assessment
climate change
heat stress
glycemic control