Use of Specialized Pro-Resolving Mediators to Alleviate Cold Platelet Storage Lesion.
Kristin M Reddoch-CardenasUmang SharmaChristi L SalgadoCarolina CantuDaniel N DarlingtonHeather F PidcokeJames A BynumAndrew P CapPublished in: Transfusion (2020)
SPM treatment, particularly Mar1 and RvD2, led to reduced platelet activation and preserved platelet function after 7 days of storage in the cold. Future work is warranted to better elucidate the mechanism of action of SPMs on cold platelet function and activation.
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