Haematologic malignancies associated with clozapine v. all other antipsychotic agents: a pharmacovigilance study in VigiBase®.

Basile ChrétienVéronique Lelong-BoulouardSylvain ChantepieMarion SassierMickael BerthoPerrine BrazoXavier HumbertJoachim AlexandreSophie FedrizziCharles Dolladille

Published in: Psychological medicine (2020)

Clozapine was significantly associated with a pharmacovigilance signal of haematologic malignancies. The risk-benefit balance of clozapine should be carefully assessed in patients with risk factors of haematologic malignancies. Clozapine should be used at the lowest effective posology.

Keyphrases

risk factors
adverse drug
drug induced
emergency department
electronic health record